Sound Science Provides Breakthrough Products

RiboCeine™

Max’s Answer to Supplementation for Effective Glutathione Production

Because glutathione (GSH) is the primary protector and detoxifier of the cell, scientists and medical professionals have looked for ways to effectively raise and support glutathione levels for years. However, glutathione cannot be effectively absorbed through the intestinal tract; so it must be made by the body itself.

The body makes (synthesizes) glutathione from three amino acids: cysteine, glycine, and glutamic acid. While glycine and glutamic acid are readily available within the body, cysteine is more difficult to make and much must be supplemented through diet.

Until recently, N-acetyl cysteine (NAC) was the only dietary supplement available to enhance the body's supply of cysteine to promote the production of glutathione. Now, Max International is proud to present RiboCeine, a critical breakthrough in cysteine supplementation for optimal glutathione production.       

RiboCeine is Proven and Patented Technology

RiboCeine is a unique molecule that combines ribose and cysteine, nutrients that are naturally occurring in humans, to more effectively deliver cysteine directly to our cells. This groundbreaking compound enters the bloodstream and delivers cysteine, as well as ribose, to the cells to stimulate the production of glutathione, the body's master antioxidant, as well as ATP, our cells’ natural fuel and source of energy.

RiboCeine has significantly outperformed other means of glutathione enhancement against which it has been tested, and has been the subject of twenty published, peer-reviewed scientific studies that were funded by the National Institutes of Health and other scientific funding agencies. RiboCeine was developed over years of research by the well-known research scientist and medicinal chemist, Herbert T. Nagasawa, Ph.D., and this technology is now patented in the United States.

Independent Studies on the Effects of Ribose-Cysteine

NOTE: The following links take you away from this page to 3rd party research sites.

1. Jurkowska, H.; Uchacz, T.; Roberts, J.; Wrobel, M. Potential therapeutic advantage of ribose-cysteine in the inhibition of astrocytoma cell proliferation Amino Acids, 2 April 2010

2. Walker, R.B.; Everette J.D., Comparative Reaction Rates of Various Antioxidants with ABTS Radical Cation. J. Agric Food Chem, 2009, 57, 1156-1161.

3. Heman-Ackah, S.E.; Juhn, S.K.; Huang, T.C.; Wiedmann, T.S. Potential therapeutic advantage of ribose-cysteine in the inhibition of astrocytoma cell proliferation. Otolaryngology-Head and Neck Surgery, 2010, 143, 429-434.

4. Oz, H.S.; Chen, T.S.; Nagasawa, H., Comparative efficacies of 2 cysteine prodrugs and a glutathione delivery agent in a colitis model. Translational Research, 2007, 150(2), 122-129.

5. Lucas Slitt, A.M.; Dominick, P.K.; Roberts, J.C.; Cohen, S.D. Effect of Ribose Cysteine Pretreatment on Hepatic and Renal Acetaminophen Metabolite Formation and Glutathione Depletion. Basic Clin. Pharmacol. Toxicol., 2005, 96 (6), 487-94.

6. Lenarczyk, M.; Ueno, A.; Vannais, D.B.; Kraemer, S.; Kronenberg, A.; Roberts, J.C.; Tatsumi, K.; Hei, T.K.; Waldren, C.A. The "Pro-drug" RibCys Decreases the Mutagenicity of High-LET Radiation in Cultured Mammalian Cells. Radiation Research, 2003, 160, 579-583.

7. Wilmore, B.H.; Cassidy, P.B.; Warters, R.L.; Roberts, J.C. Thiazolidine Prodrugs as Protective Agents against y-Radiation-Induced Toxicity and Mutagenesis in V79 Cells. J. Med. Chem., 2001, 44(16), 2661-2666.

8. Lucus, A.M.; Henning G.; Dominick, P.K.; Whiteley, H.E.; Roberts, J.C.; Cohen, S.D. Ribose Cysteine Protects Against Acetaminophen-Induced Hepatic and Renal Toxicity. Toxicologic Pathology, 2000, 28(5), 697-704.

9.Roberts, J.C.; Phaneuf, H.L.; Dominick, P.K.; Wilmore, B.H.; Cassidy, P.B. Biodistribution of [35S] - Cysteine and Cysteine Prodrugs: Potential Impact on Chemoprotection Strategies. J. Labelled Cpd. Radiopharm., 1999, 42, 485-495.

10. Roberts, J.C.; Phaneuf, H.L.; Szakacs, J.G.; Zera, R.T.; Lamb, J.G.; Franklin, M.R. Differential Chemoprotection against Acetaminophen-Induced Hepatotoxicity by Latentiated L-Cysteines. Chem. Res. Toxicol., 1998, 11, 1274-1282.

11. Bantseev, V.; Bhardwaj, R.; Rathbun, W.; Nagasawa, H.T.; Trevithick, J.R. Antioxidants and Cataract: (Cataract Induction in Space Environment and Application to Terrestrial Aging Cataract). Biochem. Mol. Bio. Intl., 1997, 42, 1189-1197.

12. Roberts, J.C.; Koch, K.E.; Detrick, S.R.; Warters, R.L.; Lubec G. Thiazolidine Prodrugs of Cysteamine and Cysteine as Radioprotective Agents. Radiation Research, 1995, 143, 203-213.

13. Carroll, M.P.; Zera, R.T.; Roberts, J.C.; Schlafmann, S.E.; Feeny, D.A.; Johnston, G.R.; West, M.A.; Bubrick, M.P. Efficacy of Radioprotective Agents in Preventing Small and Large Bowel Radiation Injury. Dis. Colon Rectum, 1995, 38(7), 716-722.

14. Roberts, J.C.;Francetic, D.J.; Zera, R.T. Chemoprotection against Cyclophosphamide-Induced Urotoxicity: Comparison of Nine Thiol Protective Agents. AntiCancer Research, 1994, 14, 389-396.

15. Rowe, J.K.; Zera, R.T.; Madoff, R.D.; Fink, A.S.; Roberts, J.C.; Johnston, G.R.; Freeney, D.A.;Young, H.L.; Bubrick, M.P. Protective Effect of RibCys Following High-Dose Irradiation of the Rectosigmoid. Dis. Colon Rectum, 1993, 36(7), 681-687.

16. Roberts, J.C.; Charyulu, R. L.; Zera, R.T.; Nagasawa, H.T. Protection Against Acetaminophen Hepatotoxicity by Ribose-Cysteine (RibCys). Pharmacology & Toxicology, 1992, 70, 281-285.

17. Roberts, J.C.; Francetic, D.J. - Mechanisms of Chemoprotection by RibCys, a Thiazolidine Prodrug of L-cysteine. Med. Chem. Res., 1991, 1, 213-219.

18. Roberts, J.C.; Francetic, D.J. Time course for the elevation of glutathione in numerous organs of L1210-bearing CDF1 mice given the L-cysteine prodrug, RibCys. Toxicology Letters, 1991, 59, 245-251.

19. Roberts, J.C.; Francetic, D.J.; Zera, R.T. L-cysteine prodrug protects against cyclophosphamide urotoxicity without compromising therapeutic activity. Cancer Chemotherapy and Pharmacology 1991, 28, 166-170.

20. Roberts, J.C.; Nagasawa, H.T.; Zera, R.T.; Fricke, R.F.; Goon, D.J. W. Prodrugs of L-cysteine as protective agents against acetaminophen-induced hepatotoxicity. 2-(polyhydroxyalky)-and 2-(Polyacetoxyalky)-Thiazolidine-4(R)-Carboxylic Acids. J. Med Chem. 1987, 30, 1891-1896.