RiboCeine Research
PLEASE
NOTE: The following links take you away from this page to 3rd party research
sites.
Roberts,
J.C.; Nagasawa, H.T.; Zera, R.T.; Fricke, R.F.; Goon, D.J. W. Prodrugs of L-cysteine as protective agents against
acetaminophen-induced hepatotoxicity. 2-(polyhydroxyalky)-and
2-(Polyacetoxyalky)-Thiazolidine-4(R)-Carboxylic Acids. J.
Med Chem. 1987, 30, 1891-1896.
Roberts,
J.C.; Francetic, D.J.; Zera, R.T. L-cysteine prodrug protects against cyclophosphamide
urotoxicity without compromising therapeutic activity. Cancer
Chemotherapy and Pharmacology 1991, 28,
166-170.
Roberts,
J.C.; Francetic, D.J. Time course for the elevation of glutathione in numerous
organs of L1210-bearing CDF1 mice given the L-cysteine prodrug, RibCys. Toxicology
Letters, 1991, 59, 245-251.
Roberts,
J.C.; Francetic, D.J. Mechanisms of Chemoprotection by RibCys, a Thiazolidine
Prodrug of L-cysteine. Med. Chem. Res., 1991, 1,
213-219.
Roberts,
J.C.; Charyulu, R. L.; Zera, R.T.; Nagasawa, H.T. Protection Against Acetaminophen Hepatotoxicity by
Ribose-Cysteine (RibCys). Pharmacology &
Toxicology, 1992, 70, 281-285.
Rowe,
J.K.; Zera, R.T.; Madoff, R.D.; Fink, A.S.; Roberts, J.C.; Johnston, G.R.;
Freeney, D.A.;Young, H.L.; Bubrick, M.P.Protective Effect of RibCys Following High-Dose
Irradiation of the Rectosigmoid. Dis. Colon
Rectum, 1993, 36(7), 681-687.
Roberts,
J.C.;Francetic, D.J.; Zera, R.T. Chemoprotection against
Cyclophosphamide-Induced Urotoxicity: Comparison of Nine Thiol Protective
Agents. AntiCancer Research, 1994, 14, 389-396.
Carroll,
M.P.; Zera, R.T.; Roberts, J.C.; Schlafmann, S.E.; Feeny, D.A.; Johnston, G.R.;
West, M.A.; Bubrick, M.P.Efficacy of Radioprotective Agents in Preventing Small
and Large Bowel Radiation Injury. Dis. Colon
Rectum, 1995, 38(7), 716-722.
Roberts,
J.C.; Koch, K.E.; Detrick, S.R.; Warters, R.L.; Lubec G. Thiazolidine Prodrugs of Cysteamine and Cysteine as
Radioprotective Agents. Radiation Research, 1995, 143, 203-213.
Bantseev,
V.; Bhardwaj, R.; Rathbun, W.; Nagasawa, H.T.; Trevithick, J.R. Antioxidants and Cataract: (Cataract Induction in Space
Environment and Application to Terrestrial Aging Cataract). Biochem.
Mol. Bio. Intl., 1997, 42, 1189-1197.
Roberts,
J.C.; Phaneuf, H.L.; Szakacs, J.G.; Zera, R.T.; Lamb, J.G.; Franklin,
M.R. Differential Chemoprotection against
Acetaminophen-Induced Hepatotoxicity by Latentiated L-Cysteines. Chem.
Res. Toxicol., 1998, 11, 1274-1282.
Roberts,
J.C.; Phaneuf, H.L.; Dominick, P.K.; Wilmore, B.H.; Cassidy, P.B. Biodistribution of [35S] - Cysteine and Cysteine
Prodrugs: Potential Impact on Chemoprotection Strategies. J.
Labelled Cpd. Radiopharm., 1999, 42,
485-495.
Lucus,
A.M.; Henning G.; Dominick, P.K.; Whiteley, H.E.; Roberts, J.C.; Cohen,
S.D. Ribose Cysteine Protects Against Acetaminophen-Induced
Hepatic and Renal Toxicity. Toxicologic
Pathology, 2000, 28(5), 697-704.
Wilmore,
B.H.; Cassidy, P.B.; Warters, R.L.; Roberts, J.C. Thiazolidine Prodrugs as Protective Agents against
y-Radiation-Induced Toxicity and Mutagenesis in V79 Cells. J.
Med. Chem., 2001, 44(16), 2661-2666.
Lenarczyk,
M.; Ueno, A.; Vannais, D.B.; Kraemer, S.; Kronenberg, A.; Roberts, J.C.;
Tatsumi, K.; Hei, T.K.; Waldren, C.A. The
"Pro-drug" RibCys Decreases the Mutagenicity of High-LET Radiation in
Cultured Mammalian Cells. Radiation Research, 2003, 160, 579-583.
Lucas
Slitt, A.M.; Dominick, P.K.; Roberts, J.C.; Cohen, S.D. Effect of Ribose Cysteine Pretreatment on Hepatic and
Renal Acetaminophen Metabolite Formation and Glutathione Depletion. Basic
Clin. Pharmacol. Toxicol., 2005, 96 (6),
487-94.
Oz, H.S.;
Chen, T.S.; Nagasawa, H., Comparative efficacies of 2 cysteine prodrugs and a
glutathione delivery agent in a colitis model. Translational
Research, 2007, 150(2), 122-129.
No comments:
Post a Comment