Friday, September 2, 2016

Vital Ingredients in MaxGXL Dr. Robert Keller, MD, MS, FACP, AAHIVS

 The Mechanisms of MaxGXL

        Let me go through the mechanisms by which the ingredients in Max work because that’s probably the easiest way to explain why it’s so important.

One of the things that goes on in your body as time passes is that:

(1)  you lose acid in your stomach (that’s a well known fact),

(2)  you lose the good bacteria in your gut.

There is cellular inflammation going on in your gut all the time because of the fact that greater than 50% of your immune system is contained within your gut, and it’s symbiotically related to the good bacteria that are in your gut–and when those start to go down, the immune system gets angry, and it gets angry by producing chemicals, and those chemicals are the ones that cause the inflammation that ultimately cause premature aging.


Vital Ingredients in MaxGXL

1.) Glutamine

         So, what did we do? The first thing we did was say, "If we are going to get this in there, we’d better do something to improve the function of the gut." So there are two independent ingredients in the Max that do that. One of them is Glutamine, which is an amino acid that has been shown in myriads of studies to essentially begin to heal the gut.


 2.) N-Acetyl Glucosamine

      Secondly, we put in N-Acetyl Glucosamine. Some of you have asked questions like, "Does glucosamine raise glucose?" No, it’s not related to glucose; it’s more related to glucosamine sulphate, which is the thing that you use to prevent arthritis (and that is in documented literature). N-Acetyl Glucosamine, because of the way it’s conformed, doesn’t really get into your joints. It promotes the layer of muco polysaccharides, which are big words that say the "slime" that coats the gut to protect it from the stuff that you put into your mouth.

      Because of foods and the food processing industry, etc. we are forever putting somewhat deleterious substances in our mouth that get into our gut that disrupt the normal function of the gut, and N-Acetyl Glucosamine goes a long way to mitigate or reduce the effects of what we
choose to eat.

Another mechanism of Max is:

3.) Cordyceps

(3) by using the Cordyceps in MaxGXL (and you’ll hear this word in a number of different functions), you reduce the amount of immune activity in the gut, and reduce the tendency
to develop the chemicals that will ultimately lead in cellular inflammation and premature aging.

So there are a lot of parts to number one, but it really does one thing.



Second, what do we do to accomplish that?

 4.) Glycine

         We have put together a whole bunch of things–and you will note in the list of ingredients for Max, there is no glycine–and Glycine is an important ingredient in the formation of glutathione. We purposely didn’t put it in because glycine is found in virtually every food you put into your mouth (whether it’s good, bad, or indifferent), so we knew you were getting enough of that. But the other two substances are glutamine (which we’ve already talked about), but it really serves two functions, one of which is to protect or heal the gut and one of which is to contribute to the formation of glutathione.


5.) N-Acetyl Cysteine

            The last, but the most important ingredient in the production of glutathione is N-Acetyl Cysteine or NAC. N-Acetyl Cysteine not dangerous. A number of people have called in or written in and emailed in and asked questions saying there is data in the literature that N-Acetyl Cysteine can be dangerous. Hogwash! There is very good data that if you keep the amount or the serving size down below 800 mg (and we are all about 1200 mg), so there is no danger to using NAC over a long period of time. But let’s just dismiss that because the people didn’t do enough research to ask the question correctly. So we put the three things together and do it in a combination that will maximize the likelihood that it is going to get through the cell and into the mitochondrial membrane, and therein the cell will produce glutathione.

           Why is that important? If you go to Goggle, 85% of the glutathione products on the market are (in fact) glutathione. There’s a real problem. First of all, even though you have reduced acids in your gut as you age, you cannot get glutathione as a molecule through the stomach without it being broken up into its constituent parts and then not being an ideal combination and in an environment where you protect the gut so it will be reabsorbed, you don’t get glutathione into the cells. IV Glutathione very expensive and cannot be recycled. You can do IV glutathione (and some of that does work), but it’s very expensive and I, frankly, do not want to sit for an IV every day to put glutathione in my body at $500 a crack! It doesn’t make a lot of sense to me.


                That other thing about that is the glutathione works once and then it’s gone–and a good portion of that glutathione is never used because glutathione is too big a molecule to squeeze through the tiny openings in the cell membrane and get inside where it needs to be used. We’ve solved that problem by putting ingredients together in an ideal combination so that the body’s path of least resistance–and the body is lazy, it’s not going to do things that are hard when it can do something that’s easier–is to make glutathione.

            So we get the glutathione in. Good! Now what do we do? It’s not only important that you get that glutathione into the cell, but it’s important that the glutathione can be used again and again and again and again. Virtually every other product on the market, whether it be reduced glutathione in some of the other "pretender" formulas that are out there (and I say that advisedly) does not allow for the recycling of glutathione.


 6.) Alpha Lipoic Acid   and    7.) vitamin C v  vitamin C - increases an enzyme called glutathione reductase

             We’ve done some extensive research and have done a number of things that will recycle glutathione. The major mechanism is the use of Alpha Lipoic Acid and vitamin C, because when glutathione is used in the mitochondria of the cell to allow the oxidative chain to work maximally to produce the maximum amount of ATP that it should, the glutathione (once it’s used) becomes oxidized, and oxidized glutathione is worthless. The way to get that re-reduced or to put it back into a utilizable form, is to use vitamin C because vitamin C increases an enzyme called glutathione reductase.

             Reductase means it takes the oxidized form and reduces it and puts it back into utilizable form, but the problem is that vitamin C is used up every time it is used, too, and it becomes oxidized. There is a trick and it’s called Alpha Lipoic Acid.

Alpha Lipoic Acid

            This doesn’t get used and it recycles vitamin C to a utilizable form, which then allows for the recycling of glutathione reductase and the reduction of glutathione. Bing, bang, boom! More glutathione for the buck!

            That was not enough, so we did a few other things. As I mentioned before, there are at least 17 enzyme systems in the body that control glutathione, and we wanted to do some things that would facilitate the maximum production of glutathione, and so there are a couple of other substances in there. Again, our friend, cordyceps. Cordyceps works (and we don’t really know the mechanism of action), but it works by increasing glutathione. In fact, in studies in the liver, if you just add cordyceps and do nothing else, and you ask the question of the glutathione production and the ATP production (which is the end result of glutathione) in the liver, it increases it by 75%. So we don’t know the the enzyme involved, but we know the ultimate result, and that is more glutathione for the buck!

8.) Silimarin (or milk thistle)    and    9.) Quercetin

Silimarin (or milk thistle)

              Addition of Silimarin and Quercetin. In addition, we put in Silimarin (or milk thistle), and by using enzymes that we’re not quite sure of, it increases glutathione production by 75%. (We just did it by 160%..not bad!)

Quercetin

              Now let’s add a third thing that’s called Quercetin, which in addition to being an antioxidant in its own right, increases enzymes called glutathione peroxidases which again increase glutathione.

             So, we have put in the ideal ingredients; we’ve allowed it to recycle as best we can–and that may change as time goes on and as I learn more–maximize the enzyme array to allow for the maximum production and recycling of glutathione–and that, in a nutshell, is what we did.

Why no Congugated Linoleic Acid?

           One of the things that has come to the fore recently is, "Why did we take out CLA? How could we do that?" We did it because after we formulated the product we found out that in order for CLA to be effective in this very complicated dance that’s involved in the production and regulation of glutathione, you need three grams of CLA. If you notice on the label, we had 100 mg in there, and that’s not going to cut it, so rather than do what all the other formulators do (and this is so rampant in the industry it’s disgusting), they put in all the ingredients that are the buzz words, but the serving sizes are so low that they wouldn’t be able to increase whatever they are trying to increase in a mouse, much less a person! I am not into "sex and sizzle." I am into science, so we took the CLA out, and it has nothing to do with our patent protection. So that kind of tells you what Max does and how it does it.
  • We improve oxidation
  • We improve ATP production
  • We reduce toxins
  • We carry poisons out of the body
  • We heal the gut
  • We give you a variety of other antioxidants which, in addition to promoting glutathione synthesis and utilization, also may have other benefits on their own

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